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BI 224436

CAS No. 1155419-89-8

BI 224436 ( BI224436 )

Catalog No. M10545 CAS No. 1155419-89-8

BI 224436 is a potent, specific, noncatalytic site integrase inhibitor (NCINI) of HIV-1 with EC50 of 11-27 nM against different HIV-1 laboratory strains.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BI 224436
  • Note
    Research use only, not for human use.
  • Brief Description
    BI 224436 is a potent, specific, noncatalytic site integrase inhibitor (NCINI) of HIV-1 with EC50 of 11-27 nM against different HIV-1 laboratory strains.
  • Description
    BI 224436 is a potent, specific, noncatalytic site integrase inhibitor (NCINI) of HIV-1 with EC50 of 11-27 nM against different HIV-1 laboratory strains, with minimal cellular cytotoxicity; exhibits a low, ～2.1-fold decrease in antiviral potency in the presence of 50% human serum andserum-shifted EC95 values ranging between 22 and 75 nM; also retains full antiviral activity against recombinant viruses encoding INSTI resistance substitutions N155S, Q148H, and E92Q; displays an additive effect in combination with most approved antiretrovirals, including INSTIs.HIV Infection Phase 1 Clinical
  • Synonyms
    BI224436
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    1155419-89-8
  • Formula Weight
    391.47
  • Molecular Formula
    C24H25NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL 112.99 mM
  • SMILES
    O=C(O)[C@H](C1=C(C2=CC(CCCO3)=C3C=C2)C4=CC=CC=C4N=C1)OC(C)(C)C
  • Chemical Name
    (2S)-[4-(3,4-Dihydro-2H-chromen-6-yl)-3-quinolinyl][(2-methyl-2-propanyl)oxy]acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fader LD, et al. ACS Med Chem Lett. 2014 Jan 22;5(4):422-7.
2. Fenwick C, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3233-44.
3. Demeulemeester J, et al. Expert Opin Ther Pat. 2014 Jun;24(6):609-32.
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